Cradle

PlatformSolutionsCompanyLicensingResourcesSign inTalk to salesTalk to salesNews:Introducing CRADLE-1 whitepaperNews:Introducing CRADLE-1 whitepaperLeverage AI to generate protein candidates and improve their properties. More breakthroughs in fewer experiments — guided by your own experimental data.Leverage AI to generate protein candidates and improve their properties. More breakthroughs in fewer experiments — guided by your own experimental data.Leverage AI to generate protein candidates and improve their properties. More breakthroughs in fewer experiments — guided by your own experimental data.Generate candidatesTrack round status easily, from generating candidates to uploading experimental results.Explore reportsManage dataGenerationReportsDataOUR CUSTOMERSTrusted by the world's top Biopharma and Industrial Bio R&D teamsThrough our partnership with Cradle, we are embedding advanced Al directly into how we innovate, enabling our teams to shorten development time and bring real-world biosolutions faster to market.Claus Fuglsang CroneChief Scientific Officer, NovonesisRead announcementRead articleRead announcementRead announcementRead articleRead announcementRecent case studiesUsing AI to produce vaccine adjuvants without cutting down rainforestEngineering therapeutic peptides with 50% success rate under tight multi-property constraints, 5× faster than prior effortsImproving Staphylococcus aureus vaccine thermostability by 2.5 °C in a single round, 7× faster than rational designOUR CUSTOMERSTrusted by the world's top Biopharma and Industrial Bio R&D teamsThrough our partnership with Cradle, we are embedding advanced Al directly into how we innovate, enabling our teams to shorten development time and bring real-world biosolutions faster to market.Claus Fuglsang CroneChief Scientific Officer, NovonesisRead announcementRead articleRead announcementRecent case studiesUsing AI to produce vaccine adjuvants without cutting down rainforestEngineering therapeutic peptides with 50% success rate under tight multi-property constraints, 5× faster than prior effortsImproving Staphylococcus aureus vaccine thermostability by 2.5 °C in a single round, 7× faster than rational designPROTEIN ENGINEERING 2.0PROTEIN ENGINEERING 2.0Compounding results across all propertiesCompounding results across all propertiesCompounding results across all properties.Get products to market in quarters, not years. Use Cradle to chart the fastest course to proteins that meet all your desired objectives. Explore further, optimize faster, and reach your destination in fewer experiments.Get products to market in quarters, not years. Use Cradle to chart the fastest course to proteins that meet all your desired objectives. Explore further, optimize faster, and reach your destination in fewer experiments.+300%+300%T7 RNAT7 RNA11223344Round ProgressRound Progresswith Cradlewith CradleCompounding resultsMove from incremental progress to compounding results with models that learn from every round of your wet lab data. Teams that use Cradle report 2-12x faster development timelines.Breakthroughs on repeatFollowing a single path puts you at risk of hitting a dead end. Instead, confidently explore multiple design strategies to bring more programs over the finish line and strengthen your IP portfolio.All projectsAll projectsmAb-HER2mAb-HER2Round 4Round 4mAb-TNFmAb-TNFCompletedCompletedvax-HPV9vax-HPV9CompletedCompletedBinding affinitySpecificityActivityStabilityExpressionCo-optimize all your propertiesActivity, binding, stability, expression, and more. Co-optimize the properties you care about, turning complex trade-offs into optimized solutions in fewer rounds.WORK ON ANY PROTEINWORK ON ANY PROTEINBuilt for any proteinand all propertiesBuilt for any protein and all properties.Accelerate your journey from hit identification to lead optimization and beyond. If you can measure it, you can optimize it with Cradle. This makes Cradle fit-for-purpose for teams developing therapeutics, agricultural solutions, food ingredients, and more.AntibodiesCraft mature and developable binders that avoid unwanted immunogenicity.AntibodiesCraft mature and developable binders that avoid unwanted immunogenicity.AntibodiesCraft mature and developable binders that avoid unwanted immunogenicity.EnzymesAccelerate specific catalytic conversions, even in challenging conditions.EnzymesAccelerate specific catalytic conversions, even in challenging conditions.EnzymesAccelerate specific catalytic conversions, even in challenging conditions.VaccinesStabilize your antigens and hit therapeutic goals faster. VaccinesStabilize your antigens and hit therapeutic goals faster. VaccinesStabilize your antigens and hit therapeutic goals faster. PeptidesGet to desired efficacy while ensuring stability.PeptidesGet to desired efficacy while ensuring stability.PeptidesGet to desired efficacy while ensuring stability.HOW CRADLE WORKSHOW CRADLE WORKSDesign in Cradle.Validate in the lab.Quickly generate lab-ready protein candidates to test in your own lab or with a CRO. Track model and candidate performance in your reports. Learn every time you add assay data.Explore platformExplore platformValidatein the labValidatein the lab44BuildBuild55TestTest66UploadUploadValidatein the lab4Build5Test6UploadDesignin CradleDesignin Cradle11LearnLearn22GenerateGenerate33ReviewReviewDesignin Cradle1Learn2Generate3ReviewLearnLearnLearn11Import your dataImport your dataTo begin, upload wet lab data from screening or optimization experiments. If you're starting a project from scratch, simply define your goals and assays to get going.Explore your data qualityExplore your data qualityCradle automatically analyses your experimental data to determine data quality and AI’s ability to learn from it. This helps you to understand how to improve your workflows and assays to get to optimal sequences faster.Models learn with youModels learn with youEvery time you upload lab results, Cradle gets better at understanding your protein. This means increasingly performant variants that get you closer to your goals— every round.GenerateGenerateGenerate22Generate candidatesGenerate candidatesThe game-changer of Cradle: new, optimized candidates at the click of a button. Choose a design strategy, set sequence- or lab based constraints, bring in your knowledge of the protein and hit ‘Generate’. No PhD in computer science needed.Multi-property supportMulti-property supportCradle learns the complex interactions between all properties of your protein. During generation, this translates into candidates that balance improved performance across properties with high scores on diversity and novelty.Full-plate optimizationFull-plate optimizationThe sequences that you download from Cradle are a carefully curated set, selected from millions of in silico designs to maximize your chances of success.ReviewReviewReview33ReportsReportsGeneration Reports give you full control over what candidates you bring to the lab and what to expect in performance. See predictive performance scores for your entire plate and explore specific sequences and mutations in 3D.Send to labSend to labNow it’s time to turn bits into atoms. Download sequences from Cradle, then order DNA and run assays in your own lab. Or send the sequences to your favorite CRO.Round statusesRound statusesTrack lab progress in Cradle using Round Statuses and see live metrics per protein property as new assay data comes in from testing.PRIVATE. SECURE. YOURSPRIVATE. SECURE. YOURSWith Cradle, your sequences and data remain private, secure, and entirely yours. Only you and those you invite can access your data, which is never used to train models for others. Protected by bank-grade security, your data stays secure at all times. Plus, you retain full ownership of your intellectual property—no royalties, just a software subscription fee.With Cradle, your sequences and data remain private, secure, and entirely yours. Only you and those you invite can access your data, which is never used to train models for others. Protected by bank-grade security, your data stays secure at all times. Plus, you retain full ownership of your intellectual property—no royalties, just a software subscription fee.Privacy-first AIPrivacy-first AIYou experimental data is only used to train your organizations custom models.SOC 2 compliantSOC 2 compliantCradle is fully SOC 2 compliant with active monitoring and tight security protocols in place.Single Sign-onSingle Sign-onSecure and simple account management with SSO support for Google and Microsoft.Custom predictorsCustom predictorsBETABETAUse internally developed predictors right in Cradle and see outputs inside Reports.Zero-maintenanceZero-maintenanceFully managed AI infrastructure with optimized GPU that scales with your need.Dedicated supportDedicated supportOur team of scientists and ML experts are ready to assist with any issues.THE CRADLE LABTHE CRADLE LABAI that gets betterevery two weeksCradle isn’t a CRO, so why do we run our own wet lab in Amsterdam? It's simple. So you get reliable and high-performing models from day one, while your proprietary data remains completely private. Much like a self-driving car company: they wouldn’t just design algorithms and cross their fingers. They need to test real-world scenarios and collect data in order to fine-tune performance. We take the same approach, ensuring our models are performant even before seeing your data.Get to know our wet labGet to know our wet labLearnings from our wet labWe put our CTO in a lab coat. Here’s what happened next.Backbone of high-throughput experimentation: Design principles for ML-ready sample trackingLab automation for faster ML-driven protein engineeringNext-level high throughput workflows: Gotta tag 'em allYou made it. Nice.Now, let's talk?I'm interestedCompanyCareersOur teamSolutionsBiopharmaIndustrial BioResourcesBlogPress kitTrust centerSecurity & privacyDocumentationConnectTalk to a Cradle expertFor academiaFollow CradleLinkedIn © 2026 · Cradle is a registered trademarkLegal TermsPrivacy PolicyCookiesBuilt with ❤️ in Amsterdam & ZurichCompanyCareersOur teamSolutionsBiopharmaIndustrial BioResourcesBlogPress kitTrust centerSecurity & privacyDocumentationConnectTalk to a Cradle expertFor academiaFollow CradleLinkedIn © 2026 · Cradle is a registered trademarkLegal TermsPrivacy PolicyCookiesBuilt with ❤️ in Amsterdam & ZurichCompanyCareersOur teamSolutionsBiopharmaIndustrial BioResourcesBlogPress kitTrust centerSecurity & privacyDocsConnectTalk to a Cradle expertFor academiaFollow CradleLinkedIn © 2026 · CradleLegal TermsPrivacy PolicyCookies --- PlatformSolutionsCompanyLicensingResourcesSign inTalk to sales/ Our platformThe AI protein engineering software built for scientistsCradle makes it easy for scientists to train and run protein AI that produces successful candidates 2 - 12x faster than traditional workflows.Wet lab validated AIUsed by leading R&D teamsIntroducing Cradle2 minutesExplore platformEndless cycles. Slow progress. Money, time, wells — wasted."This is how it's always been…" you keep hearing.For decades, it held true.Today, it changes. Scientists, meet Cradle.The AI engineering platform for biologyScientists in pharma and industrial bio use Cradle to shorten protein R&D timelines up to 12x while growing overall pipeline success.Save months of R&D timeCustomers achieve 2-12x speedups across 50+ programs. We help you reach your targets in fewer rounds by solving complex trade-offs faster.See case studiesHigher program successScientists consistently rate Cradle's AI-engineered protein candidates 8/10—delivering sequences that perform in the real world, not just in silico.See case studiesBuilt for scientistsDesigned for pharma, industrial bio, foodtech and beyond. Our agnostic approach works across modalities and data types. So if you can measure it, Cradle can help you optimize it.Explore BiopharmaExplore Industrial BioWet lab verified AIOur Amsterdam wet lab constantly validates and improves the platform's AI core, ensuring customers get AI that "just works" without worrying about maintenance or infrastructure.Learn moreThree ways AI unlocksfaster R&D timelinesSee how Cradle handles multiple complex objectives in parallel, adapts to your data and automatically de-risks every plate.Solves property trade-offs simultaneously with AITraditional methods force sequential optimization. Improve binding, then thermostability, then expression. Cradle is different. Our AI engine understands how your target properties interact and optimizes them simultaneously, finding solutions that balance competing objectives instead of sacrificing one for another.Use AI to learn from your unique experimental dataAI protein engineering explores unseen parts of the protein landscape where pre-trained models fail. After each round, Cradle automatically builds a custom model trained on public datasets, our wet lab data, and your project results to ensure accurate predictions no matter how far your designs drift from nature.AI that designs de-risked plates by defaultCradle designs curated libraries that balance hitting your objectives, learning from results, and exploring alternatives. The system runs tens of thousands of simulations to optimize between exploiting known winners and exploring new possibilities—getting you to your final candidate in the fewest rounds.All your teamsin one workspaceWith everyone in the same workspace, results compound across your organization. Same data. Same models. Same learning loop. New results.API and Web InterfaceGranular access controlsUnlimited seatsWeb InterfaceWet labAdd your domain expertise and AI generate candidates for lab testing in just a few clicks. Upload experimental results to improve your project-specific AI automatically.API AccessComputationalRun Cradle with an API and scale your expertise without the DevOps overhead. Focus on novel design strategies, not routine requests and endless configuration.Same workflow.Upgraded results.Your experimental workflow stays the same, your results don't.LearnGenerateReviewImport your dataTo begin, upload wet lab data from screening or optimization experiments. If you're starting a project from scratch, simply define your goals and assays to get going.Explore your data qualityCradle automatically analyses your experimental data to determine data quality and AI’s ability to learn from it. This helps you to understand how to improve your workflows and assays to get to optimal sequences faster.Models learn with youEvery time you upload lab results, Cradle gets better at understanding your protein. This means increasingly performant variants that get you closer to your goals— every round."Cradle’s AI-based protein design platform provides easy access and acceleration to protein optimization for the discovery pipeline."Eswar NarayananDirector, Corteva CatalystLatestupdatesData & Workflow ManagementFlexible data managementUpload data your way—define custom schemas that match your lab workflows and create focused views for specific analyses, all through our UI and API.Complete provenance trackingSee exactly who did what, when, and with which data—full audit trails for every table, task, and configuration across your projects.Full API access Connect Cradle directly to your existing pipelines and automate protein engineering workflows programmatically.Multi-modality support Engineer enzymes, peptides, and single- or multi-chain antibodies all within the same platform using both UI and API.Design and OptimizationMulti-property optimization Optimize multiple protein properties simultaneously—balance activity, stability, expression, and more in a single round to reach your target product profile faster.Modular task system Run multiple training and generation configurations side-by-side within each round to compare approaches and identify the best path forward.Advanced sequence design controls Steer your designs with template sequences, blocked mutations, regional constraints, and custom optimization objectives tailored to your project needs.Intelligent plate design Get complete experimental plates that balance achieving your objectives with exploring alternative strategies—designed through thousands of virtual simulations.Hit identification Analyze high-throughput screening and panning data to quickly identify promising candidates from large libraries.AI and model updatesAutomated model finetuning Let Cradle automatically build fit-for-purpose models for each round using public data, our proprietary wet lab data, and your specific company and project data. (Cradle models trained on your data will always be private to you. More about security and privacy on our security page.)De-risked plate generation Engineer proteins far from wild-type sequences with models trained on your experimental data to accurately predict performance in uncharted sequence space.Wet lab proven technology Our models are tested and validated continuously in our Amsterdam wet lab—every feature is built on real experimental feedback.Security and access controlEnterprise-grade security Keep your company's intellectual property safe with SSO and 2FA support for easy, secure authentication across your team.Role-based permissions Ensure the right team members can access the right projects, data, and reports with granular permission controls.Want faster results?Talk to our team today.Talk to salesAcademic programCompanyCareersOur teamSolutionsBiopharmaIndustrial BioResourcesBlogPress kitTrust centerSecurity & privacyDocumentationConnectTalk to a Cradle expertFor academiaFollow CradleLinkedIn © 2026 · Cradle is a registered trademarkLegal TermsPrivacy PolicyCookiesBuilt with ❤️ in Amsterdam & Zurich Cookie settingsCradle uses cookies to create a better experience, personalize content, and track website usage. For more details see our Cookie Policy. --- PlatformSolutionsCompanyLicensingResourcesSign inTalk to salesA modern software license. No hidden fees.One annual software license. No complicated royalty deals, no milestone payments, no hidden fees. It's that simple.Our licensesLicensing for every research need.StandardPer active projectAnnual License based on the number of projects you need. For organizations that run one to several programs.Let's talkEnterpriseScale flexiblyFor organizations with multiple projects who want to deploy Cradle across programs and divisions.Let's talkAcademicNot-for-profit researchApply to join our academic program tailored to not-for-profit research. Limited availability.Apply nowIncluded in all licensesEverything you need to get started on day one.Private and securePrivate workspace for your organizationIndustry leading security standardsYour data and models remain private to youFull ownership. Full access.Full ownership of sequence IPOwn all data and reports createdFull access to Cradle platform and APINo hidden feesUnlimited usersUnlimited data upload and storageCompute and infra includedExpert technical supportNo royalty or milestone feesPartnershipsCRO or service provider? If you wish to use or deploy Cradle as part of your service offering, please contact us here to discuss options.Contact CradleCompanyCareersOur teamSolutionsBiopharmaIndustrial BioResourcesBlogPress kitTrust centerSecurity & privacyDocumentationConnectTalk to a Cradle expertFor academiaFollow CradleLinkedIn © 2026 · Cradle is a registered trademarkLegal TermsPrivacy PolicyCookiesBuilt with ❤️ in Amsterdam & Zurich Cookie settingsCradle uses cookies to create a better experience, personalize content, and track website usage. For more details see our Cookie Policy. --- PlatformSolutionsCompanyLicensingResourcesSign inTalk to salesTalk to a Cradle expertDiscuss your needs with a Cradle expert to find the right license and support for your R&D program.Let's talk!Cradle is used and trusted by leading R&D teams CompanyCareersOur teamSolutionsBiopharmaIndustrial BioResourcesBlogPress kitTrust centerSecurity & privacyDocumentationConnectTalk to a Cradle expertFor academiaFollow CradleLinkedIn © 2026 · Cradle is a registered trademarkLegal TermsPrivacy PolicyCookiesBuilt with ❤️ in Amsterdam & Zurich Cookie settingsCradle uses cookies to create a better experience, personalize content, and track website usage. For more details see our Cookie Policy.